The course aim to provide a wider and deeper outlook of genetics topics not addressed in the course of genetics.
Special attention will be paied to the role of human genome (and epigenome) in the regulation of complex biological processes and in the individual response to endogenous and exogenous factors.
Special attention will be paied to the role of human genome (and epigenome) in the regulation of complex biological processes and in the individual response to endogenous and exogenous factors.
scheda docente
materiale didattico
- CELL CYCLE REGULATION, SENESCENCE AND APOPTOSIS. GENETIC OF AGING (GENETIC THEORIES OF AGING, GERONTOGENES AND GENES INVOLVED IN LONGEVITY, AGING IN ANIMAL MODELS, MOLECULAR AND CELLULAR AGING). CANCER GENETICS (ONCOGENES, ONCO-SUPPRESSOR GENES, CHROMOSOMAL REARRANGEMENTS INVOLVED IN CANCER, THE CANCER STEM CELLS THEORY).
- Scientific articles and teaching material provided by the teacher
Mutuazione: 20410599 Genetica molecolare in Biologia Molecolare, Cellulare e della Salute LM-6 R BERARDINELLI FRANCESCO
Programma
- GENOME (ORGANIZATION, STRUCTURAL GENOMICS, COMPARATIVE GENOMICS AND FUNCTIONAL GENOMICS). EPIGENOME (METHYLATION, HISTONE CODE, CHROMATIN 3D ARCHITECTURE, NON-CODING RNA). EXAMPLES OF EPIGENETIC REGULATION: CELL DIFFERENTIATION AND GENETIC MECHANISMS OF SEX DETERMINATION (HOW DOES SEX IS GENETICALLY DETERMINED, INACTIVATION OF X CHROMOSOME, SEX-DEPENDENT PHENOTYPIC EFFECTS).- CELL CYCLE REGULATION, SENESCENCE AND APOPTOSIS. GENETIC OF AGING (GENETIC THEORIES OF AGING, GERONTOGENES AND GENES INVOLVED IN LONGEVITY, AGING IN ANIMAL MODELS, MOLECULAR AND CELLULAR AGING). CANCER GENETICS (ONCOGENES, ONCO-SUPPRESSOR GENES, CHROMOSOMAL REARRANGEMENTS INVOLVED IN CANCER, THE CANCER STEM CELLS THEORY).
Testi Adottati
- HUMAN MOLECULAR GENETICS, Tom Strachan, Andrew Read, Zanichelli- Scientific articles and teaching material provided by the teacher
Modalità Erogazione
Lectures, classroom activities and laboratory practical experiences using fluorescence microscopes and advanced and specific analysis software.Modalità Frequenza
Mandatory attendance of at least 75% of the classesModalità Valutazione
Oral examination. The exam consists of an interview of about 30 minutes during which the student will have to answer questions relating to the topics covered during the course. The evaluation will take into account the knowledge acquired, the student's ability to integrate the information acquired, and the property and clarity of the language used. Ongoing evaluation. The professor may choose to administer two optional midterm written tests, which contribute to the final grade.