To provide knowledge on mutagenesis and repair of genetic damage starting from the concepts of classical and molecular cytogenetics. To provide theoretical and practical skills for the execution of genotoxicity tests and for the criteria for the identification of bioindicator organisms suitable for environmental biomonitoring, aimed at assessing the genotoxic risk in different environmental matrices.
scheda docente
materiale didattico
Gene and chromosomal mutations, DNA repair systems, effects of genome alterations in somatic and germline cells. Physical mutagens, chemical mutagens, and their metabolism. Genotoxic pollutants in air, water, and soil matrices. In vitro tests in prokaryotic and eukaryotic cells, in vivo tests on model organisms. Application of mutagenesis tests to environmental biomonitoring and human population biomonitoring. Basics of environmental legislation.
Programma
Gene and chromosomal mutations, DNA repair systems, effects of genome alterations in somatic and germline cells. Physical mutagens, chemical mutagens, and their metabolism. Genotoxic pollutants in air, water, and soil matrices. In vitro tests in prokaryotic and eukaryotic cells, in vivo tests on model organisms. Application of mutagenesis tests to environmental biomonitoring and human population biomonitoring. Basics of environmental legislation.
Testi Adottati
Genomica e Mutagenesi Ambientale - Various Authors - Edited by Lucia Migliore - ZanichelliModalità Frequenza
Class attendance is not mandatoryModalità Valutazione
Oral examination. The exam consists of an interview of about 30 minutes during which the student will have to answer questions relating to the topics covered during the course. The evaluation will consider the knowledge acquired, the student's ability to integrate the information acquired, and the property and clarity of the language used.