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Dipartimento di Scienze

Prof. Acconcia Filippo

Sezione: Scienze e Tecnologie Biomediche
Ruolo: Professore Associato
SC: 05/D1
Incarichi istituzionali:
Corsi: Fisiologia cellulare e molecolare
Email: filippo.acconcia@uniroma3.it
Cellulare: 81896
Indirizzo: Viale Marconi 446



10/06/2005 Ph. D. Degree in Cell Physiology University ROMA TRE, Rome Italy.
10/07/2001 Master Degree in Biology, magna cum laude, University ROMA TRE, Rome Italy.

Scientific activity

01/11/2008 up to now Assistant Professor (with National Academic Qualification as Associate Professor), Laboratory of Animal and Cell Physiology, Department of Biology, University ROMA TRE, Rome Italy. Work focuses on the molecular mechanisms of nuclear receptor biology in the regulation of cell proliferation, apoptosis and cell migration of cancer cells.
06/11/2006-17/10/2008 Post-doctoral fellow in the laboratory of Dr Simona Polo, IFOM, The FIRC Institute for Molecular Oncology, Milan, Italy.
15/01/2005-11/10/2006 Post-doctoral fellow in the laboratory of Prof Rakesh Kumar, The University of Texas, MD Anderson Cancer Center, Molecular and Cellular Oncology Department, Houston, Texas, USA.
2004 (November) Visiting Scientists in the laboratory of Guy Leclercq at the Laboratoire J.-C. Heuson de Cancerologie Mammarie, Institut Jules Bordet, Universite Libre de Bruxelles, Brussels, Belgium.

Funding ID 

2013-2015 My-First-AIRC-GRANT (12756) (Three years) ‘Investigating breast cancer: the role of estrogen receptor alpha (ERalpha) intracellular trafficking’. Grant from AIRC, Italian Association for Cancer Research.

2006-2009 Three Years Fellowship from AIRC.


2008-2013 CAL Ateneo Roma TRE.


Selected Scientific Publications

Filippo Acconcia is co-author of more than 35 scientific publications. The following list includes the last five years publications (2009-2013).
Totta P, Pesiri V, Marino M, Acconcia F (2014) Lysosomal function is involved in 17beta estradiol-induced estrogen receptor alpha degradation and cell proliferation. PLoS One. Accepted in press
La Rosa P, Pellegrini M, Totta P, Acconcia F, Marino M. (2014) Xenoestrogens Alter Estrogen Receptor (ER) α Intracellular Levels. PLoS One. 9(2):e88961.
Pesiri V, La Rosa P, Stano P, and Acconcia F (2013) Identification of an estrogen receptor alpha non covalent ubiquitin binding surface: role in 17b-estradiol-induced transcriptional activity. J Cell Sci. 126:2577-82. 
La Rosa P, Pesiri V, Leclercq G, Marino M, and Acconcia F (2012) Palmitoylation regulates 17b-Estradiol-induced Estrogen Receptor a Degradation and Transcriptional Activity. Mol. Endo. 26:762-764.
La Rosa P, Acconcia F (2011) Signaling functions of ubiquitin in the 17beta-estradiol (E2):estrogen receptor (ER) alpha network. J Steroid Biochem Mol Biol 127: 223-230
La Rosa P, Pesiri V, Marino M, Acconcia F (2011) 17beta-Estradiol-induced cell proliferation requires estrogen receptor (ER) alpha monoubiquitination. Cell Signal 23: 1128-1135.
La Rosa P, Marino M, Acconcia F (2011) 17beta-estradiol regulates estrogen receptor alpha monoubiquitination. IUBMB Life 63: 49-53.
Acconcia F, Ascenzi P, Bocedi A, Spisni E, Tomasi V, Trentalance A, Visca P, Marino M (2005) Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-estradiol. Mol Biol Cell 16: 231-237.
Acconcia F, Marino M (2011) The Effects of 17beta-estradiol in Cancer are Mediated by Estrogen Receptor Signaling at the Plasma Membrane. Front Physiol 2: 30.
Acconcia F, Sigismund S, Polo S (2009) Ubiquitin in trafficking: the network at work. Exp Cell Res 315:1610-1618.

Selected and Invited Speaker to International Scientific Conferences

2011 Selected speaker at Congress on Steroid Research Chicago, USA.
2009/2008 IDDST Annual Congress Shanghai China.
2004 Selected speaker at Nuclear Receptors 2004, The Karolinska Institutet, Huddinge, Stockholm, Sweden.


01/05/2006 Amgen Poster Award MD Anderson Cancer Center Houston Texas, USA. Best Poster in basic science in cancer research.
15/01/2013 Ambassador for the European Association for Cancer Research